1.       Mouse Xenograft Models

2.       In vitro Angiogenesis Assays

Mouse Xenograft Models

Categories

1.       Immu-Recovered Xenograft Models

2.       Living Tumor Xenograft Models

3.    Conventional Xenograft Models

Immu-Recovered Cancer Xenograft

This revolutionary enhanced xenograft model combines

· The easy of use of conventional xenograft

· The tissue fidelity of Living Tumor xenograft

· Providing recovered immunity whenever needed

Human tumor xenograft models are the mainstay of preclinical proof-of-concept testing of all experimental anti-tumor drugs.  The current mouse xenograft models have been primarily based on immunodeficient mice. However, an increasing amount of evidence suggests that immune responses may contribute to the efficacy of some therapies, such as therapies directed to cancer management.  Unfortunately, due to the nature of current xenograft models, it has been very difficult to study the role of immune responses in treatments.    
   
To address the issue of lacking immuno-response in current xenograft models, Biochain is offering a patented, revolutionary, immu-recovered xenograft model that takes into account the contribution of the immune system to the efficacy of a treatment regime.    

In this system, cancer xenograft was first established in the conventional way. Afterward, mouse T-cells were introduced back to the animal to recover and fine-tune the immu-system of the animal, as shown in the graphics below:

Living Tumor xenograft model

Living Tumor xenograft models are developed using human tumor tissues grafted in subrenal capsules of SCID mice. The human tumor tissues are developed into transplantable tumor tissue lines. These tumor tissue lines offer a sustainable tumor source for xenograft models. The model is in many aspects superior to conventional tumor model systems which are based on cultured cancer cell lines.

Features

·  Resemblance to human tumor: At the subrenal capsule graft site, the Living Tumor tissue lines retain the cell heterogeneity of the original human cancer and better retain original drug sensitivities, genotype and phenotype.

·  Predictable metastasis: Living Tumor tissue lines metastasize predictably and retain the original human tumor phenotype.

·  Wide spectrum of tumor stages: Living Tumor tissue lines represent different cancer types and a wide spectrum of early to late stage cancers.

Applications

·  Tumor growth inhibition studies

·  Orthotopic models for tumor metastatic studies

·  Tumor models for classes of therapeutic agents

·  Maximum tolerated dose, acute and subacute toxicity

·  Histopathology, Immunohistochemistry, In Situ Hybridization and qRT-PCR analysis

Description